Differences in Fecal Short-Chain Fatty Acids between Alcoholic Fatty Liver-Induced Cirrhosis and Non-alcoholic (Metabolic-Associated) Fatty Liver-Induced Cirrhosis

نویسندگان

چکیده

The objective of this study was to investigate the metabolic activity gut microbiota in cirrhosis due different variants fatty liver disease (alcoholic vs. non-alcoholic [metabolic-associated] one [AFLD and MAFLD]). present included 24 patients with alcoholic cirrhosis, 16 MAFLD-related 20 healthy controls. level spectrum short-chain acids (SCFAs) were determined via gas–liquid chromatography. All showed a decrease total content SCFAs (p < 0.001) absolute acetate 0.001), propionate butyrate isovalerate 0.001). In MAFLD significantly altered compared as evidenced by lower SCFA 0.001); higher relative IsoCn/Cn ratio Various clinical laboratory parameters correlate differently fecal their fractions AFLD MAFLD. SCFA-producing is reduced more than cirrhosis. According etiological factors disorders may be involved pathogenetic pathways.

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ژورنال

عنوان ژورنال: Metabolites

سال: 2023

ISSN: ['2218-1989']

DOI: https://doi.org/10.3390/metabo13070859